
Biomarkers to Identify Protein Metabolism Impairment in Chronic/Acute Diseases
Author(s) -
Saverio Dioguardi
Publication year - 2014
Publication title -
journal of molecular biomarkers and diagnosis
Language(s) - English
Resource type - Journals
ISSN - 2155-9929
DOI - 10.4172/2155-9929.1000177
Subject(s) - medicine , bioinformatics , biology
Clinical studies show that malnutrition and protein metabolic impairment in industrialised countries, is present\udin about 45% of elderly hospitalised patients, particularly with chronic diseases. Impairment of protein metabolism\udcauses significant loss of body proteins including muscular proteins with sarcopenia, cachexia, morbidity and\udincreased hospital stay and mortality. In anticipation of more sophisticated genetic and/or molecular biomarkers, here\udwe have presented a simple rationale for the use of repeatable biomarkers that could be performed routinely at the\udbed-side of chronic patients. This could help clinicians to early identify and monitor protein metabolism impairment.\udIdentifying and treating protein metabolism related abnormalities before they become irreversible and dangerous, is\udindispensable for the success of any therapeutic schedule