Open AccessRegulated Production of CXCL13 within the Central Nervous System
Author(s) -
David N. Irani
Publication year - 2016
Publication title -
journal of clinical and cellular immunology
Language(s) - English
Resource type - Journals
ISSN - 2155-9899
DOI - 10.4172/2155-9899.1000460
Subject(s) - cxcl13 , chemokine , compartmentalization (fire protection) , central nervous system , immunology , inflammation , biology , pathogenesis , neuroscience , cxcr5 , medicine , microbiology and biotechnology , chemokine receptor , biochemistry , enzyme
The chemokine, C-X-C motif ligand 13 (CXCL13), is constitutively expressed in lymphoid organs and controls the recruitment and compartmentalization of lymphocytes and antigen presenting cells within these specialized structures. Recent data, however, also show induction of this molecule under a variety of circumstances during central nervous system (CNS) inflammation. While its role(s) in the pathogenesis of neoplastic, infectious and autoimmune disorders of the CNS remain incompletely understood, growing evidence suggests that CXCL13 could become a relevant therapeutic target in at least some of these conditions. This review focuses on the diseases, cellular sources and external factors known to regulate CXCL13 production in the inflamed CNS.