Open AccessTh17 Cells in Protection from Tumor or Promotion of Tumor Progression
Author(s) -
Matthew R. Young
Publication year - 2016
Publication title -
journal of clinical and cellular immunology
Language(s) - English
Resource type - Journals
ISSN - 2155-9899
DOI - 10.4172/2155-9899.1000431
Subject(s) - inflammation , tumor promotion , cancer , phenotype , tumor progression , disease , immune system , immunology , medicine , cancer research , biology , bioinformatics , carcinogenesis , pathology , genetics , gene
The roles of inflammation and inflammatory cells such as Th17 cells in the development and progression of cancer have been extensively studied. However, the results have been varied, with conflicting conclusions. Most studies have focused on changes in inflammatory phenotypes once cancers have developed and disease is progressing. Far fewer studies have looked at the immune phenotypic changes that occur during progression of premalignant lesions to cancer. The impact of inflammation and, in particular, Th17 cells on tumor biology is summarized in this review, with a focus on the differences in the outcomes of studies. Possible explanations for the contradictory conclusions are also suggested.