Open AccessRestoration of Retarded Influenza Virus-specific Immunoglobulin Class Switch in Aged Mice
Author(s) -
Yongxin Zhang,
Ying Wang,
Monica Zhang,
Lin Liu,
Innocent N. Mbawuike
Publication year - 2016
Publication title -
journal of clinical and cellular immunology
Language(s) - English
Resource type - Journals
ISSN - 2155-9899
DOI - 10.4172/2155-9899.1000403
Subject(s) - immunology , elispot , antibody , adoptive cell transfer , antigen , immune system , immunoglobulin g , virus , virology , medicine , biology , t cell
The declined immune response to infection causes significant higher morbidity and mortality in aging in spite of the coexisted hyperimmunoglobulinemia (HIG). This study is to reveal the cellular basis of HIG and mechanism of weakened HA-specific IgG response in aged mice and to test cell therapy in the treatment of age-related IgG antibody production deficiency with immunocyte adoptive transfer.