Open AccessTherapeutic DNA Vaccines: The Final Step for Success
Author(s) -
Fillipe Luiz Rosa Do Carmo,
Rodrigo Dias de Oliveira Carvalho
Publication year - 2017
Publication title -
journal of bacteriology and parasitology
Language(s) - English
Resource type - Journals
ISSN - 2155-9597
DOI - 10.4172/2155-9597.1000e125
Subject(s) - dna vaccination , dna , computational biology , biology , virology , medicine , genetics , plasmid
Therapeutic DNA vaccines are mostly plasmidic constructs containing a strong promoter that allows in situ transcription and translation of one or many encoded proteins/antigens to induce protective cellular and humoral immune responses against different pathogenic organisms [1–5]. Currently, at least 114 open clinical studies are recruiting patients for distinct clinical phases using a DNAvaccine approach