Open AccessEffect of Fish oil Vs. Resolvin D1, E1, Methyl Esters of Resolvins D1 or D2 on Diabetic Peripheral Neuropathy
Author(s) -
Alexander Obrosov,
Lawrence J. Coppey,
Hanna Shevalye,
Mark A. Yorek
Publication year - 2017
Publication title -
journal of neurology and neurophysiology
Language(s) - English
Resource type - Journals
ISSN - 2155-9562
DOI - 10.4172/2155-9562.1000453
Subject(s) - menhaden , fish oil , polyunsaturated fatty acid , eicosapentaenoic acid , docosahexaenoic acid , endocrinology , medicine , food science , chemistry , biology , biochemistry , fatty acid , fish <actinopterygii> , fishery
Fish oil is enriched in omega-3 polyunsaturated fatty acids primarily eicosapentaenoic and docosahexaenoic fatty acids. Metabolites of these two polyunsaturated fatty acids include the E and D series resolvins. Omega-3 polyunsaturated fatty acids and resolvins have been reported to have anti-inflammatory and neuroprotective properties. The objective of this study was to evaluate the efficacy of menhaden oil, a fish oil derived from the menhaden, resolvins D1 and E1 and the methyl esters of resolvins D1 and D2 on diabetic peripheral neuropathy. Hypothesis being examined was that the methyl esters of resolvins D1 and D2 would be move efficacious than resolvins D1 or E1 due to an extended half-life.