Open AccessCarnitine Palmitoyltransferase 1b Deficient Mice Develop Severe Insulin Resistance After Prolonged High Fat Diet Feeding
Author(s) -
Teayoun Kim,
John F. Moore,
J. Daniel Sharer,
Kevin Yang,
Philip A. Wood,
Qinglin Yang
Publication year - 2014
Publication title -
journal of diabetes and metabolism
Language(s) - English
Resource type - Journals
ISSN - 2155-6156
DOI - 10.4172/2155-6156.1000401
Subject(s) - medicine , endocrinology , insulin resistance , skeletal muscle , insulin , adipose tissue , carnitine , biology
Carnitine palmitoyltransferase 1 (CPT1) is the rate-limiting enzyme governing the entry of long-chain acyl-CoAs into mitochondria. Treatments with CPT1 inhibitors protect against insulin resistance in short-term preclinical animal studies. We recently reported that mice with muscle isoform CPT1b deficiency demonstrated improved insulin sensitivity when fed a High Fat-Diet (HFD) for up to 5 months. In this follow up study, we further investigated whether the insulin sensitizing effects of partial CPT1b deficiency could be maintained under a prolonged HFD feeding condition.