Open AccessDiabetes Mellitus Type 1, Latent Autoimmune Diabetes of Adults and Hepatitis C Virus: What we Know and what we Need to Know
Author(s) -
Grazia Tosone Alberto Enrico Maraolo
Publication year - 2013
Publication title -
journal of diabetes and metabolism
Language(s) - English
Resource type - Journals
ISSN - 2155-6156
DOI - 10.4172/2155-6156.1000301
Subject(s) - medicine , diabetes mellitus , autoimmune diabetes , autoimmune hepatitis , need to know , type 1 diabetes , immunology , intensive care medicine , virology , hepatitis , endocrinology , computer security , computer science
Hepatitis C virus infection and diabetes mellitus are two major public health problems worldwide and the burden\udof these diseases is expected to increase in the near future. Hepatitis C virus is associated to autoimmune disorders\udof several organs (e.g. thyroid and kidney) and has recently been reported to be associated also to metabolic\uddisorders including type 2 diabetes mellitus. Biologically, the homologies between the hepatitis C virus polyprotein\udand the pancreas antigens could underlie a mechanism of molecular mimicry that could lead to autoimmune diabetes\ud(type 1 diabetes mellitus and latent autoimmune diabetes of adults). Here we review the data on the potential\udrelationship between HCV-related chronic liver disease and autoimmune mediated diabetes mellitus