Open AccessMacrophage Inflammatory Protein-3 Alpha (MIP-3α)/CCL20 in HIV-1- Infected Individuals
Author(s) -
Najib Aziz,
Roger Detels,
LiTe Chang,
Anthony W. Butch
Publication year - 2016
Publication title -
journal of aids and clinical research
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2155-6113
DOI - 10.4172/2155-6113.1000587
Subject(s) - cd38 , cd8 , macrophage inflammatory protein , medicine , immunology , chemokine , flow cytometry , ccl20 , c c chemokine receptor type 6 , inflammation , chemokine receptor , immune system , biology , genetics , stem cell , cd34
Uncontrolled HIV infection progresses to the depletion of systemic and mucosal CD4 and AIDS. Early HIV infection may be associated with increases in the concentration of MIP-3α in the blood and gut fluids. MIP-3α/CCL20 is the only chemokine known to interact with CCR6 receptors which are expressed on immature dendritic cells and both effector and memory CD8 + and CD4 + T cells. The role and prognostic value of blood levels of MIP-3α in HIV-infected individuals has yet to be described.