Open AccessQuantitative and Functional Antibody Responses to the 13-Valent Conjugate and/or 23-Valent Purified Polysaccharide Vaccine in Aging HIV-Infected Adults
Author(s) -
Jennifer A Ohtola,
Jessica Saul-McBeth,
Anita Iyer,
David J. Leggat,
Sadik A. Khuder,
Noor M. Khaskhely,
Ma Julie Westerink
Publication year - 2016
Publication title -
journal of aids and clinical research
Language(s) - English
Resource type - Journals
ISSN - 2155-6113
DOI - 10.4172/2155-6113.1000556
Subject(s) - pneumococcal polysaccharide vaccine , streptococcus pneumoniae , serotype , medicine , pneumococcal conjugate vaccine , titer , antibody , immunology , virology , conjugate vaccine , immunization , antibody titer , immunoglobulin g , pneumococcal infections , pneumococcal vaccine , microbiology and biotechnology , biology , antibiotics , pneumococcal disease
The number of aging human immunodeficiency virus-infected (HIV+) individuals living in the United States has substantially grown over the past two decades. Advanced age and HIV infection both increase susceptibility to Streptococcus pneumoniae infection due to B cell dysfunction. The combined impact of these factors on pneumococcal vaccine responses remains unknown.