Open AccessCopy Number Variation within Human β-Defensin Gene Cluster Influences Progression to AIDS in the Multicenter AIDS Cohort Study
Author(s) -
Rajeev K. Mehlotra,
Jean-Eudes Dazard,
Bangan John,
Peter A. Zimmerman,
Aaron Weinberg,
Richard J. Jurevic
Publication year - 2012
Publication title -
journal of aids and clinical research
Language(s) - English
Resource type - Journals
ISSN - 2155-6113
DOI - 10.4172/2155-6113.1000184
Subject(s) - copy number variation , medicine , multicenter aids cohort study , tropism , cohort , disease , immunology , gene , biology , human immunodeficiency virus (hiv) , genetics , viral disease , sida , virus , genome
DEFB4/103A encoding β-defensin 2 and 3, respectively, inhibit CXCR4-tropic (X4) viruses in vitro. We determined whether DEFB4/103A Copy Number Variation (CNV) influences time-to-X4 and time-to-AIDS outcomes.