Open AccessFrequencies of Functional Polymorphisms in Three Pharmacokinetic Genes of Clinical Interest within the Admixed Puerto Rican Population
Author(s) -
Carmelo Orengo-Mercado,
Bianca Nieves,
Lizbeth López,
Nabila Vallés-Ortiz,
Jessicca Y. Renta,
Pedro J. Santiago-Borrero,
Carmen L. Cadilla,
Jorge Duconge
Publication year - 2013
Publication title -
journal of pharmacogenomics and pharmacoproteomics
Language(s) - English
Resource type - Journals
ISSN - 2153-0645
DOI - 10.4172/2153-0645.1000113
Subject(s) - genotyping , cyp2c19 , genotype , genetics , allele frequency , allele , biology , puerto rican , population , cyp2d6 , gene , demography , sociology , anthropology
This cross-sectional study was aimed at determining the allele frequencies for the CYP2C19*2, CYP2C19*3, CYP2D6*10 and PON1 (rs662) polymorphisms in the Puerto Rican population. The CYP2C19, CYP2D6 and PON1 genes are known to be associated with functional changes in drug metabolism and activation. Individuals carrying the aforementioned polymorphisms are at a higher risk of suffering from drug-induced adverse events and/ or unresponsiveness from a variety of drugs that includes antidepressants, atypical antipsychotics and antiplatelet compounds. Information on the frequency of these polymorphisms is more commonly found on homogeneous populations, but is scarce in highly heterogeneous populations like Hispanics, as in the case of Puerto Ricans.