Open AccessThe TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling
Author(s) -
Jintao Zhang,
Dong Zhang,
Yun Pan,
Xiaofei Liu,
Jiawei Xu,
Xinrui Qiao,
Wenjing Cui,
Liang Dong
Publication year - 2022
Publication title -
allergy, asthma and immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 45
eISSN - 2092-7363
pISSN - 2092-7355
DOI - 10.4168/aair.2022.14.2.233
Subject(s) - gene knockdown , ovalbumin , tumor necrosis factor alpha , asthma , medicine , immunology , proinflammatory cytokine , small interfering rna , mucus , receptor , inflammation , microbiology and biotechnology , chemistry , biology , transfection , cell culture , apoptosis , antigen , biochemistry , ecology , genetics
Tumor necrosis factor-like ligand 1A (TL1A), especially its secreted form, has been shown to contribute to eosinophilic inflammation and mucus production, cardinal features of asthma, through its receptor, death receptor 3 (DR3). However, the role of the TL1A-DR3 axis in asthma, especially in terms of airway remodeling, has not yet been fully understood.