Open AccessDupilumab Therapy Improves Stratum Corneum Hydration and Skin Dysbiosis in Patients With Atopic Dermatitis
Author(s) -
SeungJu Lee,
Song-Ee Kim,
KyongOh Shin,
Kyungho Park,
Sang Eun Lee
Publication year - 2021
Publication title -
allergy, asthma and immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 45
eISSN - 2092-7363
pISSN - 2092-7355
DOI - 10.4168/aair.2021.13.5.762
Subject(s) - dupilumab , eczema area and severity index , atopic dermatitis , transepidermal water loss , stratum corneum , dysbiosis , microbiome , dermatology , staphylococcus aureus , medicine , barrier function , immunology , pathology , biology , disease , bacteria , bioinformatics , genetics , microbiology and biotechnology
We aimed to investigate the effects of dupilumab on 1) the permeability and antimicrobial barrier, 2) the composition of the skin microbiome, and 3) the correlation between changes in skin barrier properties and microbiota in atopic dermatitis (AD) patients.