Open AccessPresence of IgE Autoantibodies Against Eosinophil Peroxidase and Eosinophil Cationic Protein in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis
Author(s) -
Jorge Sánchez,
Andrés Sánchez,
Marlon Múnera,
Elizabeth García,
Juan-Felipe López,
Margarita María VelásquezLopera
Publication year - 2021
Publication title -
allergy, asthma and immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 45
eISSN - 2092-7363
pISSN - 2092-7355
DOI - 10.4168/aair.2021.13.5.746
Subject(s) - immunoglobulin e , eosinophil peroxidase , eosinophil cationic protein , immunology , eosinophil , epitope , medicine , atopic dermatitis , allergy , antibody , asthma
Eosinophils are frequently found in atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) that release eosinophil peroxidase (EPX) and eosinophil cationic protein (ECP). Continuous exposure to these proteins could trigger an autoimmune response which may contribute to the pathogenesis and severity of skin inflammation. In this study, we investigate the immunoglobulin E (IgE) response against eosinophil proteins in CSU and AD.