Open AccessATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1
Author(s) -
Na Liu,
Yuchen Feng,
Huicheng Liu,
Wenliang Wu,
Yucheng Liang,
Pingfei Li,
Zhengping Wei,
Min Wu,
Zhao Hui Tang,
Junyan Han,
Xiang Cheng,
Zheng Liu,
Arian Laurence,
Hua-Bin Li,
Guohua Zhen,
Yang Xiang
Publication year - 2021
Publication title -
allergy, asthma and immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 45
eISSN - 2092-7363
pISSN - 2092-7355
DOI - 10.4168/aair.2021.13.3.479
Subject(s) - asthma , immunology , ovalbumin , macrophage polarization , medicine , ccl17 , pathogenesis , macrophage , inflammation , chemistry , chemokine , immune system , biochemistry , in vitro , cxcl10
Macrophages are important regulators of environmental allergen-induced airway inflammation and asthma. ATP6V0d2 is a subunit of vacuolar ATPase highly expressed in macrophages. However, the functions of ATP6V0d2 in the regulation of pathogenesis of allergic asthma remain unclear. The aim of this study is to determine the function and related molecular mechanisms of macrophage protein ATP6V0d2 in allergic asthma.