Open AccessEffect of an Antagonistic Peptide of CCR5 on the Expression of Autophagy-related Genes and β-Arrestin 2 in Lung Tissues of Asthmatic Mice
Author(s) -
Juan Liu,
Rongrong Liang,
Huarong Huang,
Yingli Zhang,
Aicen Xie,
Yingqiang Zhong
Publication year - 2021
Publication title -
allergy, asthma and immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 45
eISSN - 2092-7363
pISSN - 2092-7355
DOI - 10.4168/aair.2021.13.1.106
Subject(s) - peptide , autophagy , biology , inflammation , microbiology and biotechnology , gene expression , vacuole , chemistry , gene , immunology , biochemistry , cytoplasm , apoptosis
The mechanisms of CC chemokine receptor 5 (CCR5) in the process of autophagy remain unknown. In this study, we examined the role of HY peptide, which is an antagonistic peptide specifically binding the second extracellular loop of CCR5, in the expression of autophagy genes and β-arrestin 2 in lung tissues of asthmatic mice.