A Case of Sorafenib-induced DRESS Syndrome in Hepatocelluar Carcinoma | Zendy

Dong Kyun Kim | Zendy; Sung Woo Lee | Zendy; Hwa Seong Nam | Zendy; Dong Sub Jeon | Zendy; Na Rae Park | Zendy; YoungHee Nam | Zendy; Soo Keol Lee | Zendy; Yang Hyun Baek | Zendy; Sang Young Han | Zendy; Sung Wook Lee | Zendy

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A Case of Sorafenib-induced DRESS Syndrome in Hepatocelluar Carcinoma

Author(s) -

Dong Kyun Kim,

Sung Woo Lee,

Hwa Seong Nam,

Dong Sub Jeon,

Na Rae Park,

YoungHee Nam,

Soo Keol Lee,

Yang Hyun Baek,

Sang Young Han,

Sung Wook Lee

Publication year - 2016

Publication title -

korean journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.203

H-Index - 25

eISSN - 2233-6869

pISSN - 1598-9992

DOI - 10.4166/kjg.2016.67.6.337

Subject(s) - sorafenib , medicine , hepatocellular carcinoma , rash , eosinophilia , cirrhosis , dermatology , liver function , adverse effect , gastroenterology , oncology

Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms (DRESS) syndrome. Here, we report a case of 72-year-old man with HCC and alcoholic liver cirrhosis who developed skin eruptions, fever, eosinophilia, and deteriorated hepatic and renal function under sorafenib treatment. He has since successfully recovered with conservative care.

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