Open AccessReduction of oocyte lipid droplets and meiotic failure due to biotin deficiency was not rescued by restoring the biotin nutritional status
Author(s) -
Akira Tsuji,
Yuka Ikeda,
Mutsumi Murakami,
Yasuko Kitagishi,
Satoru Matsuda
Publication year - 2022
Publication title -
nutrition research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2022.16.3.314
Subject(s) - oocyte , biotin deficiency , lipid metabolism , lipid droplet , biotin , lipogenesis , endocrinology , biology , medicine , meiosis , biochemistry , andrology , chemistry , microbiology and biotechnology , embryo , gene
Oocyte lipid droplets play a crucial role in meiosis and embryo development. Biotin is associated with fatty acid synthesis and is the coenzyme for acetyl-CoA carboxylase (ACC). The effects of a biotin deficiency on the oocyte lipid metabolism remain unknown. This study examined the effects of a biotin deficiency and its replenishment on murine 1) oocyte lipid droplet levels, 2) ovary lipid metabolism, and 3) oocyte meiosis.