Open AccessSchisandrae Fructus ethanol extract attenuates particulate matter 2.5-induced inflammatory and oxidative responses by blocking the activation of the ROS-dependent NF-κB signaling pathway
Author(s) -
Hyesook Lee,
Cheol Park,
Da Hye Kwon,
Hyun Hwangbo,
So Young Kim,
Min Yeong Kim,
Seon Yeong Ji,
Da Hye Kim,
JinWoo Jeong,
GiYoung Kim,
HyeJin Hwang,
Yung Hyun Choi
Publication year - 2021
Publication title -
nutrition research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2021.15.6.686
Subject(s) - oxidative stress , chemistry , proinflammatory cytokine , antioxidant , reactive oxygen species , pharmacology , nitric oxide , inflammation , nf κb , nitric oxide synthase , signal transduction , biochemistry , medicine , immunology , organic chemistry
Schisandrae Fructus, the fruit of Schisandra chinensis Baill., has traditionally been used as a medicinal herb for the treatment of various diseases, and has proven its various pharmacological effects, including anti-inflammatory and antioxidant activities. In this study, we investigated the inhibitory effect of Schisandrae Fructus ethanol extract (SF) on inflammatory and oxidative stress in particulate matter 2.5 (PM2.5)-treated RAW 264.7 macrophages.