Open AccessHesperetin suppresses LPS/high glucose-induced inflammatory responses via TLR/MyD88/NF-κB signaling pathways in THP-1 cells
Author(s) -
Aeri Lee,
HyunJi Gu,
Min-Hee Gwon,
JungMi Yun
Publication year - 2021
Publication title -
nutrition research and practice
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2021.15.5.591
Subject(s) - hesperetin , hesperidin , proinflammatory cytokine , inflammation , pharmacology , tlr2 , nf κb , chemistry , tumor necrosis factor alpha , interleukin 6 , medicine , endocrinology , antioxidant , biochemistry , flavonoid , tlr4 , alternative medicine , pathology
Unregulated inflammatory responses caused by hyperglycemia may induce diabetes complications. Hesperetin, a bioflavonoid, is a glycoside in citrus fruits and is known to have antioxidant and anticarcinogenic properties. However, the effect of inflammation on the diabetic environment has not been reported to date. In this study, we investigated the effect of hesperetin on proinflammatory cytokine secretion and its underlying mechanistic regulation in THP-1 macrophages with co-treatment LPS and hyperglycemic conditions.