Open AccessCurcumin and hesperetin attenuate D-galactose-induced brain senescencein vitroandin vivo
Author(s) -
Jihye Lee,
Yoo Sun Kim,
Eunju Kim,
Yerin Kim,
Yuri Kim
Publication year - 2020
Publication title -
nutrition research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2020.14.5.438
Subject(s) - neuroprotection , curcumin , senescence , hesperetin , pharmacology , superoxide dismutase , antioxidant , in vivo , glutathione peroxidase , neun , neurodegeneration , biochemistry , chemistry , medicine , biology , microbiology and biotechnology , immunohistochemistry , flavonoid , disease
Brain senescence causes cognitive impairment and neurodegeneration. It has also been demonstrated that curcumin (Cur) and hesperetin (Hes), both antioxidant polyphenolic compounds, mediate anti-aging and neuroprotective effects. Therefore, the objective of this study was to investigate whether Cur, Hes, and/or their combination exert anti-aging effects in D-galactose (Dg)-induced aged neuronal cells and rats.