Open AccessGastric ulcer healing by chebulinic acid solid dispersion-loaded gastroretentive raft systems: preclinical evidence
Author(s) -
Poonam Negi,
Surbhi Gautam,
Aditi Sharma,
Charul Rathore,
Lalit Sharma,
Navneet Kumar Upadhyay,
Murtaza M. Tambuwala,
Dinesh Kumar Chellappan,
Gaurav Gupta,
Parteek Prasher,
Kamal Dua,
Shweta Agarwal,
Uma Ranjan Lal
Publication year - 2022
Publication title -
therapeutic delivery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 46
eISSN - 2041-6008
pISSN - 2041-5990
DOI - 10.4155/tde-2021-0062
Subject(s) - raft , bioadhesive , terminalia chebula , omeprazole , bioavailability , famotidine , biopharmaceutical , pharmacology , chemistry , gastric acid , aqueous solution , dissolution , solubility , chromatography , polymer , medicine , stomach , biochemistry , traditional medicine , copolymer , organic chemistry , biology , genetics
Background: Chebulinic acid (CA), a component in Terminalia chebula, exhibits antiulcer activity, but has poor aqueous solubility. Raft-forming systems incorporating solid dispersions (SDs) of CA, were developed to overcome its poor biopharmaceutical properties and to prolong the gastric residence time for maximum activity. Methods: SDs were formulated by a solvent evaporation method using Eudragit EPO. Raft formulations consisted of sodium alginate as a polymer. Results: Release of CA in the dissolution medium was 40%, whereas SDs showed 95.45% release. The CA raft system (20 mg/kg) showed curative efficacy in an alcohol-induced gastric ulcer model and increased protection when compared with omeprazole (10 mg/kg) and CA suspension (20 mg/kg). Conclusion: These studies demonstrated SD raft systems to be a promising approach for antiulcer therapy by CA.