Open AccessRole of nasal casts for in vitro evaluation of nasal drug delivery and quantitative evaluation of various nasal casts
Author(s) -
Per G. Djupesland,
John Messina,
Ramy Mahmoud
Publication year - 2020
Publication title -
therapeutic delivery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.619
H-Index - 46
eISSN - 2041-6008
pISSN - 2041-5990
DOI - 10.4155/tde-2020-0054
Subject(s) - nose , nasal administration , deposition (geology) , medicine , biomedical engineering , nuclear medicine , drug delivery , materials science , anatomy , pharmacology , nanotechnology , biology , paleontology , sediment
Background: Nasal casts may characterize intranasal drug deposition. Methodology: The Koken cast, described as ‘anatomically correct’, and the Optinose cast, derived from MRI of a healthy male during velum closure, were dimensionally compared and assessed for deposition assessment suitability. Results: Smallest vertical cross-sectional areas (valve region) for Koken and Optinose right/left: 2.55/2.75 and 1.18/1.18 cm 2 , respectively, versus a ‘normative’ mean (range) of 0.85 cm 2 (0.2–1.6 cm 2 ). Intranasal volumes differed (computed tomography/water fill): Koken, 35.8/38.6 cm 3 and Optinose, 24.1/25.0 cm 3 , versus a ‘normative’ mean (range) of 26.4 cm 3 (20.9–31.1 cm 3 ). Conclusion: Koken cast dimensions are larger than the normal range and the Optinose cast. The validity of casts for regulatory drug deposition studies is suspect.