Evaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine | Zendy

Basim M. Ayesh | Zendy; Ahmed Shaker Abu Shaaban | Zendy; Abdalla Asaf Abed | Zendy

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Evaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine

Author(s) -

Basim M. Ayesh,

Ahmed Shaker Abu Shaaban,

Abdalla Asaf Abed

Publication year - 2018

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.4155/fsoa-2017-0112

Subject(s) - vkorc1 , cyp2c9 , warfarin , palestine , pharmacogenetics , medicine , pharmacology , biology , algorithm , genetics , genotype , computer science , gene , atrial fibrillation , history , ancient history

Aim: To evaluate applicability of CYP2C9*2 , *3 and VKORC1–1639G > A based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients. Patients & methods: Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD. Results: Frequency of CYP2C9*2 , *3 and VKORC1–1639G > A alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R 2 = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R 2 = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7). Conclusion: The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.

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