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Aim:  To evaluate applicability of  CYP2C9*2 ,  *3  and  VKORC1–1639G > A  based algorithm to predict warfarin stable dose (WSD) in a group of Palestinian patients.    Patients & methods:  Warfarin doses were retrospectively calculated for 101 Palestinian patients under warfarin therapy using three models. Performance of the three models was assessed in 47 patients found to take WSD.    Results:  Frequency of  CYP2C9*2 ,  *3  and  VKORC1–1639G > A  alleles is 13.6, 0.0 and 46.5% respectively. The international warfarin pharmacogenetics consortium algorithm was more reliable (MAE = 8.9 ± 1.4; R 2  = 0.350) than both the clinical algorithm (MAE = 10.4 ± 1.4; R 2  = 0.128;) and the fixed-dose algorithm (MAE = 11.1 ± 1.7).    Conclusion:  The international warfarin pharmacogenetics consortium algorithm can be reliably applied for predicting the WSD in Palestinian population.

Evaluation of CYP2C9- and VKORC1-based pharmacogenetic algorithm for warfarin dose in Gaza-Palestine