Open AccessAn emerging role of KRAS in biogenesis, cargo sorting and uptake of cancer-derived extracellular vesicles
Author(s) -
Zhijack Fong,
Wai Leng Lee
Publication year - 2022
Publication title -
future medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.708
H-Index - 69
eISSN - 1756-8927
pISSN - 1756-8919
DOI - 10.4155/fmc-2021-0332
Subject(s) - kras , microvesicles , endosome , biogenesis , endocytic cycle , biology , crosstalk , extracellular vesicles , microbiology and biotechnology , secretion , cancer , cancer research , intracellular , microrna , endocytosis , gene , cell , genetics , biochemistry , colorectal cancer , physics , optics
Extracellular vesicles (EVs) are nanovesicles secreted for intercellular communication with endosomal network regulating secretion of small EVs (or exosomes) that play roles in cancer progression. As an essential oncoprotein, Kirsten rat sarcoma virus (KRAS) is tightly regulated by its endosomal trafficking for membrane attachment. However, the crosstalk between KRAS and EVs has been scarcely discussed despite its endocytic association. An overview of the oncogenic role of KRAS focusing on its correlation with cancer-associated EVs should provide important clues for disease prognosis and inspire novel therapeutic approaches for treating KRAS mutant cancers. Therefore, this review summarizes the relevant studies that provide substantial evidence linking KRAS mutation to EVs and discusses the oncogenic implication from the aspects of biogenesis, cargo sorting, and release and uptake of the EVs.