Open AccessConcepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases
Author(s) -
Daljeet Singh Dhanjal,
Parvarish Sharma,
Meenu Mehta,
Murtaza M. Tambuwala,
Parteek Prasher,
Keshav Raj Paudel,
Gang Liu,
Shakti D. Shukla,
Philip M. Hansbro,
Dinesh Kumar Chellappan,
Kamal Dua,
Saurabh Satija
Publication year - 2022
Publication title -
future medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.708
H-Index - 69
eISSN - 1756-8927
pISSN - 1756-8919
DOI - 10.4155/fmc-2021-0081
Subject(s) - medicine , airway , inflammation , drug delivery , intensive care medicine , bioinformatics , immunology , biology , chemistry , surgery , organic chemistry
Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.