Open AccessBioanalytical techniques for detecting biomarkers of response to human asbestos exposure
Author(s) -
Clementina Mesaros,
Andrew J. Worth,
Nathaniel W. Snyder,
Melpo ChristofidouSolomidou,
Anil Vachani,
Steven Μ. Albelda,
Ian A. Blair
Publication year - 2015
Publication title -
bioanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.566
H-Index - 58
eISSN - 1757-6199
pISSN - 1757-6180
DOI - 10.4155/bio.15.53
Subject(s) - asbestos , mesothelioma , immune system , lung cancer , lung function , medicine , bioanalysis , toxicology , immunology , pathology , biology , lung , nanotechnology , materials science , metallurgy
Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.