Open AccessCircular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression
Author(s) -
Xianqi Feng,
Shumin Nie,
Jiuzuo Huang,
T L Li,
Jingjing Zhou,
W Wang,
Likun Zhuang,
Fanjun Meng
Publication year - 2020
Publication title -
neoplasma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.628
H-Index - 50
eISSN - 1338-4317
pISSN - 0028-2685
DOI - 10.4149/neo_2018_181129n908
Subject(s) - myeloid leukemia , peripheral blood mononuclear cell , pathogenesis , leukemia , myeloid , biology , gene expression profiling , downregulation and upregulation , chronic myelogenous leukemia , immunology , gene expression , cancer research , gene , medicine , genetics , in vitro
Increasing evidence demonstrate that circular RNAs (circRNAs) play critical role in regulation of gene expression, which participate in the pathogenesis of cancer, including chronic myeloid leukemia (CML). In this study, we aimed to investigate the expression profiling of circHIPK3 in CML. We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. Our findings provide insights on the role of circHIPK3 in the development and treatment of CML.