Open AccessFBLN3 inhibits the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway
Author(s) -
Haiyan Mao,
S. P. Liu,
Guimei Kong,
Yongfen Xu,
Yongfen Xu,
Guo-Zhuang Sun,
Z. Wang,
Fei Han,
Jie Tong,
Ping Bo
Publication year - 2019
Publication title -
neoplasma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.628
H-Index - 50
eISSN - 1338-4317
pISSN - 0028-2685
DOI - 10.4149/neo_2018_180703n441
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , fibulin , cancer research , metastasis , apoptosis , colorectal cancer , cell growth , cell culture , signal transduction , cancer , chemistry , biology , medicine , microbiology and biotechnology , genetics , extracellular matrix
Fibulin-3(FBLN3) levels are different in different types of cancers. We found that fibulin-3 was downregulated in colorectal (CRC) cells, particularly in the SW480 cell line. By comparison, transfecting SW480 cells with a lentivirus overexpressing fibulin-3 RNA could inhibit proliferation, induce G1/S arrest, and promote cell apoptosis. Fibulin-3 overexpression further suppressed the invasion and metastasis of CRC. These effects were regulated through the AKT/mTOR signaling pathway.