FBLN3 inhibits the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway | Zendy

Haiyan Mao | Zendy; S.-P. Liu | Zendy; Guimei Kong | Zendy; Yongfen Xu | Zendy; Yanmin Xu | Zendy; Guozhuang Sun | Zendy; Z. Wang | Zendy; Fei Han | Zendy; J.-D. Tong | Zendy; Ping Bo | Zendy

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FBLN3 inhibits the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway

Author(s) -

Haiyan Mao,

S.-P. Liu,

Guimei Kong,

Yongfen Xu,

Yanmin Xu,

Guozhuang Sun,

Z. Wang,

Fei Han,

J.-D. Tong,

Ping Bo

Publication year - 2019

Publication title -

neoplasma

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.628

H-Index - 50

eISSN - 1338-4317

pISSN - 0028-2685

DOI - 10.4149/neo_2018_180703n441

Subject(s) - pi3k/akt/mtor pathway , protein kinase b , fibulin , cancer research , metastasis , apoptosis , colorectal cancer , cell growth , cell culture , signal transduction , cancer , chemistry , biology , medicine , microbiology and biotechnology , genetics , extracellular matrix

Fibulin-3(FBLN3) levels are different in different types of cancers. We found that fibulin-3 was downregulated in colorectal (CRC) cells, particularly in the SW480 cell line. By comparison, transfecting SW480 cells with a lentivirus overexpressing fibulin-3 RNA could inhibit proliferation, induce G1/S arrest, and promote cell apoptosis. Fibulin-3 overexpression further suppressed the invasion and metastasis of CRC. These effects were regulated through the AKT/mTOR signaling pathway.

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