Open AccessMechanisms regulating radiosensitivity of glioma stem cells
Author(s) -
Y Liu,
Yu-hui Shen,
Ting Sun,
Wei-Zhong Yang
Publication year - 2017
Publication title -
neoplasma
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.628
H-Index - 50
eISSN - 1338-4317
pISSN - 0028-2685
DOI - 10.4149/neo_2017_502
Subject(s) - radioresistance , radiosensitivity , glioma , wnt signaling pathway , cancer research , stem cell , radiation therapy , pi3k/akt/mtor pathway , biology , temozolomide , medulloblastoma , medicine , signal transduction , microbiology and biotechnology
Malignant glioblastoma (GBM) has become a very common and difficult brain tumor given its low cure rate and high recurrence rate. GBMs are resistant to treatments because glioma stem cells (GSCs)/glioma-initiating cells (GICs), a specific subpopulation of GBM, possess properties of tumor stem cells, such as unlimited proficiency, self-renewal, differentiation and resistance to chemotherapy and radiotherapy, and exhibit a very strong DNA repair capability. Radiotherapy has become a preponderant treatment, and researchers have found many significant tumor microenvironmental factors and valuable signaling pathways regulating the GSC radioresistance, including NOTCH, Wnt/β-catenin, Hedgehog, STAT3, and PI3K/AKT/mTOR. Therefore, we seek to boost GSC radiosensitivity through activating or inactivating pathways alone or together to eliminate the likely source of glioma and prolong survival of patients.