Open AccessSmoking, hormonal factors and molecular markers in female lung cancer
Author(s) -
Diana Schveigert,
Arnoldas Krasauskas,
Janina Didžiapetrienė,
D Kalibatiene,
Saulius Cicėnas
Publication year - 2016
Publication title -
neoplasma
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.628
H-Index - 50
eISSN - 1338-4317
pISSN - 0028-2685
DOI - 10.4149/neo_2016_402
Subject(s) - lung cancer , oncology , medicine , tobacco smoke , hormone , cancer , disease , incidence (geometry) , carcinogen , lung , lung cancer susceptibility , gene , physiology , biology , genetics , single nucleotide polymorphism , environmental health , physics , genotype , optics
There has been substantial argumentation about differences in lung cancer occurrence and characteristics between men and women. Lung cancer incidence suggests that gender-related factors may influence lung cancer risk. The carcinogenic effect of tobacco smoke and the use of hormone replacement therapy could result in susceptibility to lung cancer among women. Mutations in EGFR and HER-2/neu genes, and ROS1 gene fusions may also play a role in gender-based survival rate differences. This review summarizes the latest data of disease markers and its usefulness in female lung cancer.