Open AccessCathepsin S as a cancer target
Author(s) -
L Zhang,
H Wang,
Jin Xu
Publication year - 2015
Publication title -
neoplasma
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.628
H-Index - 50
eISSN - 1338-4317
pISSN - 0028-2685
DOI - 10.4149/neo_2015_003
Subject(s) - cathepsin , cathepsin a , cathepsin s , cancer , angiogenesis , cancer research , proteases , metastasis , cathepsin e , cathepsin l , cathepsin o , basement membrane , chemistry , biology , medicine , microbiology and biotechnology , biochemistry , enzyme
Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Multiple studies indicate that cathepsin S acts not only as a crucial role in antigen presentation but also as an important protagonist of cancers. Cathepsin S has been shown to participate in dissolution and remodelling of connective tissue and basement membranes, resulting in the process of tumor growth, invasion, metastasis and angiogenesis. Therefore, cathepsin S has been suggested as a potential therapeutic target in cancer therapy. In the present study, we review the rapidly advancing field of cathepsin S in cancer therapy, highlighting the specific roles of cathepsin S in cancer.