Open AccessPost-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus
Author(s) -
Magdaléna Chmelová,
Daniela Ježová,
I Riečanský,
Nataša Hlaváčová
Publication year - 2019
Publication title -
general physiology and biophysics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.376
H-Index - 39
eISSN - 1338-4325
pISSN - 0231-5882
DOI - 10.4149/gpb_2019019
Subject(s) - enos , vascular endothelial growth factor , medicine , endocrinology , gene expression , weaning , biology , vascular endothelial growth factor b , gene , vegf receptors , hippocampus , vascular endothelial growth factor c , regulator , vascular endothelial growth factor a , nitric oxide synthase , nitric oxide , genetics
The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolation-induced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed.