The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor | Zendy

Zsuzsanna Magyar | Zendy; Gyula Diszházi | Zendy; Judit Péli-Szabó | Zendy; Péter Szentesi | Zendy; Claude Collet | Zendy; László Csernoch | Zendy; Péter P. Nánási | Zendy; János Almássy | Zendy

Open Access

The diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor

Author(s) -

Zsuzsanna Magyar,

Gyula Diszházi,

Judit Péli-Szabó,

Péter Szentesi,

Claude Collet,

László Csernoch,

Péter P. Nánási,

János Almássy

Publication year - 2019

Publication title -

general physiology and biophysics

Language(s) - English

Resource type - Journals

eISSN - 1338-4325

pISSN - 0231-5882

DOI - 10.4149/gpb_2019007

Subject(s) - ryanodine receptor , endoplasmic reticulum , skeletal muscle , chemistry , receptor , biophysics , ryanodine receptor 2 , action (physics) , channel (broadcasting) , microbiology and biotechnology , medicine , biology , biochemistry , endocrinology , physics , engineering , electrical engineering , quantum mechanics

Very recently, the diamide insecticide chlorantraniliprole was shown to induce Ca2+-release from sarcoplasmic reticulum (SR) vesicles isolated from mammalian skeletal muscle through the activation of the SR Ca2+ channel ryanodine receptor. As this result raises severe concerns about the safety of this chemical, we aimed to learn more about its action. To this end, single-channel analysis was performed, which showed that chlorantraniliprole induced high-activity bursts of channel opening that accounts for the Ca2+-releasing action described before.

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