Open AccessThe diamide insecticide chlorantraniliprole increases the single-channel current activity of the mammalian skeletal muscle ryanodine receptor
Author(s) -
Zsuzsanna Magyar,
Gyula Diszházi,
Judit Péli-Szabó,
Péter Szentesi,
Claude Collet,
László Csernoch,
Péter P. Nánási,
János Almássy
Publication year - 2019
Publication title -
general physiology and biophysics
Language(s) - English
Resource type - Journals
eISSN - 1338-4325
pISSN - 0231-5882
DOI - 10.4149/gpb_2019007
Subject(s) - ryanodine receptor , endoplasmic reticulum , skeletal muscle , chemistry , receptor , biophysics , ryanodine receptor 2 , action (physics) , channel (broadcasting) , microbiology and biotechnology , medicine , biology , biochemistry , endocrinology , physics , engineering , electrical engineering , quantum mechanics
Very recently, the diamide insecticide chlorantraniliprole was shown to induce Ca2+-release from sarcoplasmic reticulum (SR) vesicles isolated from mammalian skeletal muscle through the activation of the SR Ca2+ channel ryanodine receptor. As this result raises severe concerns about the safety of this chemical, we aimed to learn more about its action. To this end, single-channel analysis was performed, which showed that chlorantraniliprole induced high-activity bursts of channel opening that accounts for the Ca2+-releasing action described before.