Open AccessThe plasma level of glutamic acid decarboxylase 65 (GAD65) increased in severely autistic Iranian children
Author(s) -
Somayeh Vazifekhah,
Shahram Barfi,
F. Soleimany,
Amirhossein Aliakbar,
Fahime Zavvari,
F. Karimzadeh
Publication year - 2022
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2022_054
Subject(s) - autism , glutamate decarboxylase , childhood autism rating scale , biomarker , glutamatergic , etiology , autism spectrum disorder , medicine , plasma levels , neurodevelopmental disorder , psychology , glutamate receptor , endocrinology , psychiatry , gastroenterology , enzyme , biochemistry , chemistry , receptor
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. The major etiological mechanism lies in glutamatergic/GABAergic imbalance. The aim of this study was to evaluate the plasma levels of glutamic acid decarboxylase 65 (GAD65) protein in mildly and severely autistic patients, and also to compare plasma GAD65 concentration in mild and severe autism.