Open AccessA new perspective on the pleiotropic blood pressure improvement effect of sitagliptin: downregulation of miRNA-155 and miRNA-21
Author(s) -
M Yilmaz-Bozoglan K Gul-Kahraman,
I Serhatlioglu,
Erhan Önalan,
M C Akkopru,
Engin Şahna
Publication year - 2021
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2021_145
Subject(s) - sitagliptin , blood pressure , medicine , endocrinology , microrna , asymmetric dimethylarginine , type 2 diabetes mellitus , glycemic , diabetes mellitus , pharmacology , chemistry , arginine , biochemistry , amino acid , gene
Deterioration of vascular responses is the crucial event in the initiation of cardiovascular problems in hypertension (HT) and diabetes mellitus (DM). A well-known oral antidiabetic, sitagliptin, has pleiotropic effects besides improving glycemic state in type-2 DM. This study aimed to investigate the therapeutic effect of sitagliptin on blood pressure with previously unassessed parameters of well-known pathophysiological processes and especially at the microRNA (miRNA) level where there are many unknowns.