The effect of maternal sleep deprivation on differentiation of mesenchymal stem cells in the presence of neonates brain cerebrospinal fluid of Wistar rats | Zendy

Sheila Shariat | Zendy; Kazem Parivar | Zendy; Nasim Hayati Roodbari | Zendy; Mohammad Nabiuni | Zendy

Open Access

The effect of maternal sleep deprivation on differentiation of mesenchymal stem cells in the presence of neonates brain cerebrospinal fluid of Wistar rats

Author(s) -

Sheila Shariat,

Kazem Parivar,

Nasim Hayati Roodbari,

Mohammad Nabiuni

Publication year - 2020

Publication title -

bratislavské lekárske listy/bratislava medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 32

eISSN - 1336-0345

pISSN - 0006-9248

DOI - 10.4149/bll_2020_024

Subject(s) - nestin , neun , mesenchymal stem cell , neural stem cell , stem cell , biology , andrology , cerebrospinal fluid , endocrinology , medicine , microbiology and biotechnology , immunology , immunohistochemistry

Cerebrospinal fluid (CSF) contains proliferation, differentiation and maturation signals that are essential factors for brain development. Due to presence of such factors this fluid has proliferative and differentiation potential. A previous study showed that maternal sleep deprivation (MSD) decrease the number of newborn neurons in development of hippocampus. Also, it impairs hippocampus-dependent spatial learning and memory in the young offspring rat. MSD can change CSF factors. In the present study, the effect of MSD-CSF on differentiation of mesenchymal stem cells to neural cells was examined, and expression of Nestin, Neun, and NeurD1 that are neurogenic markers was investigated.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research