MicroRNAs expression profiles as biomarkers and therapeutic tools in Turkish patients with chronic myeloid leukemia | Zendy

Murat Yurt | Zendy; Orhan Ayyıldız | Zendy; Abdullah Karakuş | Zendy; Ayşe Feyda Nursal | Zendy; Hilmi İsi | Zendy

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MicroRNAs expression profiles as biomarkers and therapeutic tools in Turkish patients with chronic myeloid leukemia

Author(s) -

Murat Yurt,

Orhan Ayyıldız,

Abdullah Karakuş,

Ayşe Feyda Nursal,

Hilmi İsi

Publication year - 2020

Publication title -

bratislavské lekárske listy/bratislava medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.387

H-Index - 32

eISSN - 1336-0345

pISSN - 0006-9248

DOI - 10.4149/bll_2020_023

Subject(s) - myeloid leukemia , microrna , medicine , biomarker , chromosomal translocation , gene expression , oncology , breakpoint cluster region , gene , bioinformatics , immunology , biology , receptor , genetics

In 95 % of Chronic myeloid leukemia (CML) patients, chromosomal translocation resulting in the formation of the Philadelphia (Ph) chromosome (t:9;22) is observed, which in turn leads to the formation of the BCR-ABL fusion gene. MicroRNAs (miRNAs) are a group of small and non-coding RNAs modulating gene expression via binding to the target mRNAs. We aimed to characterize the expression profiles of various miRNAs in different stages of Ph(+) CML patients.

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