Open AccessMicroRNAs expression profiles as biomarkers and therapeutic tools in Turkish patients with chronic myeloid leukemia
Author(s) -
Murat Yurt,
Orhan Ayyıldız,
Abdullah Karakuş,
Ayşe Feyda Nursal,
Hilmi İsi
Publication year - 2021
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2020_023
Subject(s) - myeloid leukemia , microrna , medicine , biomarker , chromosomal translocation , gene expression , oncology , breakpoint cluster region , gene , bioinformatics , immunology , biology , receptor , genetics
In 95 % of Chronic myeloid leukemia (CML) patients, chromosomal translocation resulting in the formation of the Philadelphia (Ph) chromosome (t:9;22) is observed, which in turn leads to the formation of the BCR-ABL fusion gene. MicroRNAs (miRNAs) are a group of small and non-coding RNAs modulating gene expression via binding to the target mRNAs. We aimed to characterize the expression profiles of various miRNAs in different stages of Ph(+) CML patients.