Open AccessApoptotic effects of thymol, a novel monoterpene phenol, on different types of cancer
Author(s) -
Hülya Elbe,
Gürkan Yiğittürk,
Türker Çavuşoğlu,
Yiğit Uyanıkgil,
Feral Öztürk
Publication year - 2021
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2020_016
Subject(s) - thymol , du145 , apoptosis , chemistry , mtt assay , cancer , pharmacology , lung cancer , viability assay , thymus vulgaris , cancer cell , cancer research , biochemistry , biology , medicine , food science , essential oil , lncap
Cancer is a major public health problem in many areas of the world. Many anticancer drugs in current clinical use have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) is an oxygenated aromatic compound from monoterpene group. It is the main constituent of thyme essential oil and shows antioxidant, antiseptic and antiproliferative properties. The aim of this study is to determine the antiproliferative activity and apoptotic effect of thymol on prostate cancer (PC-3, DU145), breast cancer (MDA-MB-231), and lung cancer (KLN205) cell lines.