Open AccessDecreased plasma levels of 25(OH)D in multiple sclerosis patients. Correlation with disease severity expressed by EDSS, MSSS, progression index and Herbert´s scale severity grade
Author(s) -
Mária Bucová,
Vladimı́ra Ďurmanová,
Daniela Cudrakova,
S Blažíĉková,
Karin Gmitterová,
Eleonóra Klímová,
Iveta Lisa,
Kristína Klučková,
Beata Majernikova
Publication year - 2019
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2019_120
Subject(s) - pathogenesis , multiple sclerosis , vitamin d and neurology , medicine , expanded disability status scale , immune system , inflammation , immunology , vitamin d deficiency , autoimmune disease , disease , endocrinology , gastroenterology
Multiple sclerosis is a chronic inflammatory and autoimmune demyelinating disease of the brain and spinal cord. Vitamin D has anti-inflammatory and anti-Th1, Th17 activities, activates the function of regulatory T cells, shifts the immune response towards Th2, so it might be favorable for downregulation of the disease pathogenesis, and if inflammation and Th1 and Th17 immunity are hyperactivated. The aim of our study was to highlight the role of vitamin D in multiple sclerosis pathogenesis.