Anti-tumor effects of lidocaine on human gastric cancer cells in vitro | Zendy

LiuQing Ye | Zendy; Y. Zhang | Zendy; Y J Chen | Zendy; Q. Liu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Anti-tumor effects of lidocaine on human gastric cancer cells in vitro

Author(s) -

LiuQing Ye,

Y. Zhang,

Y J Chen,

Q. Liu

Publication year - 2019

Publication title -

bratislavské lekárske listy/bratislava medical journal

Language(s) - English

Resource type - Journals

eISSN - 1336-0345

pISSN - 0006-9248

DOI - 10.4149/bll_2019_036

Subject(s) - lidocaine , cancer , apoptosis , cancer cell , p38 mitogen activated protein kinases , medicine , in vitro , mapk/erk pathway , cancer research , pharmacology , chemistry , anesthesia , signal transduction , biochemistry

Currently, there exists an urgent need to investigate the anti-cancer effects of lidocaine on gastric cancer cells. The purpose of the present study was to evaluate the anti-tumor effects and the underlying mechanisms of lidocaine in gastric cancer cells. Our results indicated that lidocaine significantly suppressed proliferation, migration and invasion and induced apoptosis in a dose-dependently manner in human gastric cancer cells. In addition, our data shown that the expression of Bcl-2 was decreased and the level of Bax was increased by lidocaine treatment. Furthermore, we found that lidocaine altered the protein expression of the MAPK pathway. p-p38 was also increased simultaneously, while the level of p38 was not changed. In summary, lidocaine has a prominent anti-tumor activity on gastric cancer cells and is a promising therapeutic agent for the treatment of gastric cancer (Fig. 4, Ref. 32). Keywords: lidocaine, gastric cancer cells, anti-tumor effect, MAPK pathway.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research