Open AccessHistopathological efficiency of amifostine in radiation‑induced heart disease in rats
Author(s) -
İclal Gürses,
Murat Özeren,
M. Serin,
Nur Yücel,
Haldun Şükrü Erkal
Publication year - 2018
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2018_011
Subject(s) - amifostine , fibrosis , medicine , vasculitis , cardiac fibrosis , radiation therapy , pathology , necrosis , cardiology , urology , disease
Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long‑term protective effect on heart tissue in an experimental rat model.