Open AccessAssociation of angiogenic cytokines (VEGF-A and VEGF-C) and clinical characteristic in women with unexplained recurrent miscarriage
Author(s) -
Alireza Bagheri,
Pratap Kumar,
Asha Kamath,
Pragna Rao
Publication year - 2017
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2017_051
Subject(s) - miscarriage , medicine , vascular endothelial growth factor , angiogenesis , abortion , pregnancy , recurrent miscarriage , vegf receptors , gestation , obstetrics , gynecology , gastroenterology , biology , genetics
Recurrent miscarriage (RM) defined as 2 or more spontaneous miscarriage before 20 weeks of gestation, affects at least 1 % of couples trying to conceive. In over 50 % of cases, the cause of the loss of pregnancy remains unexplained. Reduced expression of Angiogenic factors such as: vascular endothelial growth factor (VEGF-A) and VEGF-C has been linked with spontaneous miscarriage, likely due to defective foetal and placental angiogenesis.