Open AccessAberrant promoter hypermethylation of p16, survivin, and retinoblastoma in gastric cancer
Author(s) -
Li Guo,
Chuanbing Huang,
Qing Ji
Publication year - 2017
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2017_033
Subject(s) - survivin , retinoblastoma , cancer research , cancer , dna methylation , medicine , biology , genetics , gene , gene expression
Gastric cancer is common and can be found throughout the world. Notoriously like other cancers, gastric cancer is a consequence of cellular regulation disorder. Epigenetics, including many oncogenes or tumour suppressor genes, can provide some clues for this kind of disorder. DNA methylation, especially promoter methylation, which causes the silence/decrease of tumour related genes, has become a focus in various tumour types. The aim of this study was to investigate promoter methylation of certain genes: p16, survivin, retinoblastoma (Rb), all of which have been regarded as genes related to gastric cancer.