Open AccessAdenosine A1 receptor modifies P53 expression and apoptosis in breast cancer cell line Mcf-7
Author(s) -
Mehdi Nikbakht Dastjerdi,
Ali Valiani,
Mohammad Mardani,
Mahdi Zamani
Publication year - 2016
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2016_046
Subject(s) - mcf 7 , apoptosis , agonist , flow cytometry , adenosine receptor , receptor expression , biology , receptor , cell culture , cancer research , cancer cell , microbiology and biotechnology , chemistry , cancer , medicine , biochemistry , human breast , genetics
Breast cancer cells over-express the adenosine receptor A1 and in most of these cells, P53 gene is a wild type. Because of this finding and relationship between A1 receptor and cell apoptosis and proliferation, this study aimed to determine the effect of agonist and antagonist of A1 receptor on cell apoptosis and proliferation and recognize the relationship between this receptor and P53 expression.