Open AccessPreimplantation genetic diagnosis of X-linked diseases examined by indirect linkage analysis
Author(s) -
Irena Borgulová,
Martina Putzová,
И. А. Солдатова,
L Krautova,
Ľubomíra Pecnová,
J Míka,
Radomír Křen,
P Potuznikova,
D. Stejskal
Publication year - 2015
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2015_103
Subject(s) - preimplantation genetic diagnosis , embryo transfer , genetics , embryo , proband , pregnancy , biology , gynecology , medicine , obstetrics , mutation , gene
Many centers of assisted reproduction in the Czech Republic offer preimplantation genetic diagnosis with fluorescent in situ hybridization (FISH) to couples requiring preimplantation genetic diagnosis (PGD) of X-linked diseases. However, this process results in discarding all male embryos and is not able to distinguish a carrier or healthy female embryo in X-linked recessive disorders.