Open AccessThe effect of polyethylene glycol adhesion barrier (Spray Gel) on preventing peritoneal adhesions
Author(s) -
Fatih Daşıran,
Ramazan Eryılmaz,
Arda Işık,
İsmail Okan,
A Somay,
Mustafa Şahi̇n
Publication year - 2015
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2015_072
Subject(s) - adhesion , fibrosis , polypropylene , hernia repair , wound healing , fibroblast , inflammation , medicine , tissue adhesion , hernia , materials science , surgery , chemistry , pathology , immunology , composite material , biochemistry , in vitro
The prominent cells in the late phase of wound healing during proliferation and matrix deposition are fibroblasts. Foreign materials in the operation site like prosthesis prolong the inflammation and induce fibroblast proliferation (8). 3 different prostheses used in this study induced chronic inflammation and fibrosis and provided an effective repair. Dense and thick adhesions due to fibrosis also induced strong adhesions to omentum and small intestine if only polypropylene mesh used for hernia repair. However, there was no difference between SprayGel treated polypropylene mesh and Sepramesh when compared for fibrosis. It also prevents the intraabdominal adhesion formation. It is nontoxic, sticky adherent, non- immigrant and easy to use both in open and laparoscopic surgeries. This experimental study revealed that polyethyleneglycol applied polypropylene mesh accomplishes hernia repair with significantly less adhesion formation than polypropylene mesh alone while securing a remarkable economy than adhesion barrier coated dual meshes (Tab. 6, Fig. 7, Ref. 23). Text in PDF www.elis.sk.