Open AccessThe decrease in NKG2D+ Natural Killer cells in peripheral blood of patients with metastatic colorectal cancer
Author(s) -
Marjan Gharagozloo,
H Rezaei Kalantari,
Abbas Rezaei,
Mohammad Reza Maracy,
Maryam Salehi,
Afshin Bahador,
Niloofar Hassannejad,
Mohammad Narimani,
Mohammad Hossein Sanei,
Behnaz Bayat,
H Ghazanfari
Publication year - 2015
Publication title -
bratislavské lekárske listy/bratislava medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 32
eISSN - 1336-0345
pISSN - 0006-9248
DOI - 10.4149/bll_2015_056
Subject(s) - nkg2d , colorectal cancer , peripheral blood mononuclear cell , immune system , cd8 , natural killer cell , medicine , cytotoxic t cell , immunology , flow cytometry , cancer , cancer research , biology , in vitro , biochemistry
Natural killer (NK) cells play important roles in the immune defense against tumors such as colorectal cancer. In humans, NKG2D is an activating immune receptor constitutively expressed in most cytotoxic lymphocytes including NK and CD8+ T cells. In this study, the expression of NKG2D molecule was investigated in peripheral blood NK cells from colorectal cancer patients and compared with healthy subjects.