MicroRNA-185 reduces the expression of hepatitis B virus surface antigen by targeting PRKCH in HepG2 2.2.15 cells | Zendy

Ruiqian Zhang | Zendy; Zhong Liu | Zendy; Xilin Hou | Zendy; Mo Wang | Zendy; Y. Xiong | Zendy; Hongjian Lu | Zendy; Ying Wang | Zendy; Jia Su | Zendy; Yongjiang Liu | Zendy; Guomin Zhang | Zendy; Yujun Liu | Zendy

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MicroRNA-185 reduces the expression of hepatitis B virus surface antigen by targeting PRKCH in HepG2 2.2.15 cells

Author(s) -

Ruiqian Zhang,

Zhong Liu,

Xilin Hou,

Mo Wang,

Y. Xiong,

Hongjian Lu,

Ying Wang,

Jia Su,

Yongjiang Liu,

Guomin Zhang,

Yujun Liu

Publication year - 2020

Publication title -

acta virologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.412

H-Index - 33

eISSN - 1336-2305

pISSN - 0001-723X

DOI - 10.4149/av_2020_304

Subject(s) - virology , antigen , hepatitis b virus , virus , microrna , biology , microbiology and biotechnology , immunology , gene , genetics

MicroRNAs (miRNAs) are single-stranded noncoding RNAs with 18 to 25 nucleotides and play critical roles in a wide spectrum of biological processes. We repored that miR-185 inhibited hepatitis B surface antigen (HBsAg) expression and hepatitis B virus (HBV) replication without affecting the proliferation of HepG2 2.2.15 cells, compared with the controls. We identified that protein kinase C eta (PRKCH) is a direct target gene of miR-185 that affects HBV replication and protein expression and that the miR-185 may suppress HBV replication. Our results provide more information for gene therapy in HBV infection. Keywords: miR-185; HBV; HBV surface antigen; viral replication; PRKCH.

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